Abstract Description: The U.S. Environmental Protection Agency’s (EPA) 325A and 325B programs are critical components of fenceline monitoring, providing essential data on air quality and emissions in communities near industrial facilities. Traditionally, this program has focused on the oil and gas and refinery sectors but is now also moving into synthetic organic chemical manufacturing with the HON MACT. These programs are characterized by their rigorous sampling protocols and frequent, ongoing sample collection, creating a large number of samples which can pose significant logistical and operational challenges. Over several years of laboratory operations working with a variety of industrial and consulting clients, we have seen a number of key lessons emerge, particularly in the area of communication between the laboratory and onsite team members. Effective collaboration between these teams is crucial to ensure accurate sample processing, timely analysis, and consistent data quality, as well as contextualizing potentially non-conforming data. This presentation will explore the importance of clear and continuous communication in maintaining the integrity of the monitoring process, highlighting strategies for overcoming challenges and ensuring the success of fenceline monitoring initiatives. Using practical examples, we will illustrate how seamless coordination enhances both operational efficiency and the reliability of data in the context of air quality monitoring.